Santa Fe won comfortably as Atletico Nacional maintained their fantastic begin for the Copa Libertadores.
Atletico Nacional advanced towards the final 16 inside the Copa Libertadores having a 4-0 thrashing of Penarol on Tuesday.
Objectives from Jonathan Copete, Daniel Bocanegra, Orlando Berrio and Luis Ruiz saw the Colombian outfit to their win in Montevideo.
Copete opened the scoring inside the eighth minute, finding around the finish of an Alexis Henriquez pass just before finishing in a one-on-one.
The guests had to wait till first-half further time for you to double their lead, Bocanegra curling a brilliant 25-yard free-kick in to the major corner.
The win was sealed late on as Berrio and Ruiz, the latter with a cheeky chip, struck.
Atletico have won all 4 of their Group four matches to sit eight points clear of Sporting Cristal, with Penarol having earned just one particular point.
Fellow Colombian side Santa Fe also enjoyed a win, beating Cobresal 3-0 in Group eight thanks to a Jonathan Gomez brace.
They may be level on points with Cerro Porteno atop the group, with Corinthians one behind and Cobresal bottom.
A aim in every single half saw Independiente del Valle to a 2-0 victory at property to Melgar in Group five, when San Lorenzo and Gremio played out a scoreless draw.